Phosphatidylinositol polyphosphates: ionization constants in fluid phosphatidylcholine model membranes
نویسندگان
چکیده
منابع مشابه
Absence of clustering of phosphatidylinositol-(4,5)-bisphosphate in fluid phosphatidylcholine.
Phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] plays a key role in the modulation of actin polymerization and vesicle trafficking. These processes seem to depend on the enrichment of PI(4,5)P(2) in plasma membrane domains. Here, we show that PI(4,5)P(2) does not form domains when in a fluid phosphatidylcholine matrix in the pH range of 4.8-8.4. This finding is at variance with the sponta...
متن کاملUndulating Charged Fluid Membranes and their Bending Constants
We consider harmonically undulating ionic surfactant membranes, calculating a general expression for the bending modulus valid for all salt and surfactant concentrations, and surface charge densities. This is achieved through a perturbative expansion of the meanfield electrostatic potential and free energy about a planar reference state, consisting of two parallel planar membranes with interven...
متن کاملA phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes
SEC14p is required for protein transport from the yeast Golgi complex. We describe a quantitative analysis of yeast bulk membrane and Golgi membrane phospholipid composition under conditions where Golgi secretory function has been uncoupled from its usual SEC14p requirement. The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membra...
متن کاملIonization Constants pKa of Cardiolipin
Cardiolipin is a phospholipid found in the inner mitochondrial membrane and in bacteria, and it is associated with many physiological functions. Cardiolipin has a dimeric structure consisting of two phosphatidyl residues connected by a glycerol bridge and four acyl chains, and therefore it can carry two negative charges. The pKa values of the phosphate groups have previously been reported to di...
متن کاملTunable generic model for fluid bilayer membranes.
We present a model for the efficient simulation of generic bilayer membranes. Individual lipids are represented by one head bead and two tail beads. By means of simple pair potentials these robustly self-assemble to a fluid bilayer state over a wide range of parameters, without the need for an explicit solvent. The model shows the expected elastic behavior on large length scales, and its physic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.lb274